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Newly diagnosed wife and mother shares her story

Meet Jen, a wife and mother from Rhode Island who is living life in the face of her late-stage diagnosis. She shares her ...

Newly diagnosed wife and mother shares her story

Meet Jen, a wife and mother from Rhode Island who is living life in the face of her late-stage diagnosis. She shares her experiences with diagnosis, biomarker testing, and making treatment decisions.

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JEN:

I’m a physician. I am an anesthesiologist. I was in private practice for almost 14 years, living my very busy life in the suburbs of Boston, and, just sort of getting by day to day on little sleep and, um, raising my kids as best I could and, um, yeah, everything sort of changed on that—that day.

I had had this lingering cough that would wax and wane. It seemed like it would come and go. We thought most likely I was just sort of getting re-infected. I have young children and they tend to bring home a lot of, um, germs. So everybody just assumed I had a cold, um, and I would take a course of antibiotics and it would get a little bit better, but it never really went away, and it always sort of found its way back. It was so sort of routine for me that I didn’t even notice it anymore. That was just what I did; I coughed.

I was at work, and so at the end of the day the ENT surgeon said to me, you know, you’ve been coughing all day. I think we should get a chest x-ray. I said okay, so he ordered it for me.

We got the x-ray and he called me with the results and he said, Jen, there’s something on your chest x-ray. And I was like what do you mean something? He said I don’t know. There’s something there.

And so that was sort of the start of my journey. That’s when things changed for me.

TEXT ON SCREEN: JEN

Living With Lung Cancer

TEXT ON SCREEN:

I was diagnosed with stage IV, non-small cell lung cancer, with an EGFR-positive mutation.

JEN:

My name is Jen. I am 45 years old. I was diagnosed with stage IV, non-small cell lung cancer, with an EGFR-positive mutation.

Shock was the first thing. I went through—I think shock lasted a while. Denial a little bit, but just like shock. How could this be? I, you know, like why would I get lung cancer? I’m young, I’m healthy. I don’t smoke. It just didn’t make sense. I was just, you know, completely flabbergasted.

That’s how I was and I was like that probably for a week, just shaking and cold and scared. And then, you know, the more I talked to people, the more I talked to doctors, I started to feel better. I started to do research on my own and educate myself, almost immediately. And the more I read, the more hopeful I became, because there is reason to hope. I tried to stay away from statistics because they’re just that. They’re statistics and they’re scary, and so for the first probably two months of my diagnosis I wouldn’t even look at the statistics.

I needed, for me, I needed an oncologist that was going to be able to tell me that don’t worry about statistics, that you’re one person, and that we can work with you. And that’s what I was looking for. That’s all I wanted to hear from my oncologist, is someone who would work with me, and know that I’m an individual, that I’m a person, that I want to live.

So the first thing that happened after I met with the oncologist, um, was he suggested we get a biopsy, to know what we’re dealing with.

I actually didn’t know, that when I was diagnosed that there were specific medications that can be used to target specific mutations on the tumor cells. I only knew of chemotherapy. Um, and so when I was first diagnosed, I assumed I would be getting standard traditional chemotherapy and then my oncologist explained to me that, in fact, they would take the tumor and they would test it and look to see if there were any specific mutations that may be able to be targeted with current medications.

TEXT ON SCREEN:

The time from testing to receiving results varies.

JEN:

Waiting is hard, um, but what I’ve found is that it’s better to wait a few days for your results to come back and then be able to start the most beneficial treatment for you. These targeted therapies are going to target your mutation specifically, so if you can hold on for a few days until those results come back, I would recommend doing that.

TEXT ON SCREEN:

A “mutation” is any change in the DNA sequence of a cell. In non-small cell lung cancer, mutation testing can help doctors find out detailed information about a tumor, which can help determine treatment options for your type of lung cancer.

JEN:

I said, I have a mutation. Which one do I have? And he said you have the EGFR mutation and I said, great, so that means we can target it and he said absolutely we can target it. And so that was the beginning of my treatment.

I had done a little research over the course of the week, but I was really in patient-mode and I was depending on my oncologist to — to guide me. And so when I met with him in the office, he said I have this drug.

It’s called TAGRISSO and let’s start you on that immediately. So he was the one who told me about it, and suggested that that might be the best course of treatment for me.

VOICE OVER AND TEXT ON SCREEN:

TAGRISSO is a prescription medicine for non-small cell lung cancer that has spread to other parts of the body. TAGRISSO is used as a first treatment if tumors have certain abnormal epidermal growth factor receptor genes. 80 mg available by prescription only.

TEXT ON SCREEN:

TAGRISSO can cause serious side effects. These can lead to death.

JEN:

My doctor told me about some of the side effects that I might expect.

TEXT ON SCREEN:

Tell your doctor right away if you have lung problems, heart problems, eye problems or skin problems.

JEN:

When I started taking the medication, at first, I think I felt just a little bit tired, a little more tired than usual. And I quickly adapted to that. And other than that, maybe a little bit of dry skin.

I take it one pill a day. I take it at night before I go to sleep and that’s it, one pill a day. You know when you’re first diagnosed with such a devastating disease, you’re in this sort of dark hole and anything — you just think that you’ll never be able to live a normal life, that nothing will ever be the same, that you’ll never be happy again and that you might as well start preparing because this is —this is it.

So I appreciate all the little things that I took for granted before. I find myself sort of stopping and just looking at things I never would have noticed before, whether it’s, you know, the water or the flowers or just anything, the sky. I’ve found that I’m — that I’m just living my life every day to the fullest that I can. Things that used to bother me do not bother me anymore. I’m very grateful for every day that I’m here.

I can play with the kids. I can go for a walk, go for a hike. I can do whatever I need to do, spend time with family, friends.

I’m living with lung cancer.

VOICE OVER AND TEXT ON SCREEN:

TAGRISSO is an FDA-approved oral targeted therapy for metastatic non-small cell lung cancer with certain abnormal EGFR gene(s).

TAGRISSO may cause serious side effects. These could lead to death. Tell your doctor right away if you have lung problems, such as trouble breathing, shortness of breath, cough, or fever; heart problems, such as pounding or racing, swelling of your ankles and feet, feeling lightheaded; eye problems, such as watery, red, sensitive, or painful eyes; or skin problems, such as skin reactions that look like rings, or severe blistering or peeling of the skin. Tell your doctor about all your medical conditions and any medicines you take, and if you are pregnant or plan to become pregnant, or are breastfeeding.

The most common side effects of TAGRISSO are diarrhea, rash, dry skin, changes in your nails, mouth sores, tiredness, and decreased appetite. These are not all the possible side effects.

TEXT ON SCREEN:

Please see Important Safety Information and full Prescribing Information for TAGRISSO, including Patient Information, available at TAGRISSO.com.

If you can’t afford your medication, AstraZeneca may be able to help.

TAGRISSO is a registered trademark of the AstraZeneca group of companies. ©2020 AstraZeneca. All rights reserved. US-35788 Last Updated 1/20

Biomedical Researcher Finds Motivation After Her Diagnosis and Shares How She Is Doing Now

Meet Shobha, a wife and mother to 2 daughters living and working in Richmond, Virginia, as a biomedical researcher. She shares her treatment journey with metastatic EGFR-mutation positive non-small cell lung cancer, and how her diagnosis motivated her and her loved ones to fight it together. Watch as Shobha tells us what she’s learned, why biomarker testing is important, and how she found out that TAGRISSO® (osimertinib) was the right choice for treating her metastatic non-small cell lung cancer with abnormal EGFR genes.

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TEXT ON SCREEN:

Shobha is a real patient and this is her personal story. The diagnosis pathway and experience can vary from person to person.

SHOBHA:

It all started last year in September 2018, having trouble breathing, having persistent cough is what led me to seek some medical intervention at that time.

TEXT ON SCREEN:

At this point, Shobha sought out a primary physician to perform a series of tests.

SHOBHA:

Immediately, that triggered off setting a bronchoscopy, taking biopsy samples, sending those samples off for analysis and in first week of December when I was told that I have metastatic lung cancer.

TEXT ON SCREEN: Metastatic:

When the cancer has spread to other parts of the body.

SHOBHA

Living with Lung Cancer


“I’m living currently with metastatic EGFR+ non-small cell lung cancer.”

SHOBHA:

I'm married and I have two daughters, and I'm a biomedical researcher. My name is Shobha and I'm living currently with metastatic EGFR positive lung cancer. The day I was called into the doctor’s office to tell me about the diagnosis…and all my physicians are there, I know them personally. In fact, the physician who did my bronchoscopy and finally called me into his office to tell me the diagnosis…I've known him for more than 20 years. And it must have been very hard for him, and I walked into his clinic and he just asked about my husband. He says, oh, is Sid not going to be here with you? And I said, why? Do you want me to call him? And that interaction itself told me that it is a little more serious.

TEXT ON SCREEN:

Sid, Shobha’s Husband

SID:

In spite of the initial shock, we just backed each other up and we said, no. We are not going to yield to this. And she was very, very strong. I was actually encouraged by her more than I'm encouraging her. She was more encouraging that way and said, we'll fight it. Don't worry.

TEXT ON SCREEN:

The time from testing to receiving results varies. Talk to your doctor about your treatment plan.

SHOBHA

When I go back to that day sitting in his office, I did not have any fear or any negative thought about anything. All I could think was, okay, what do we do next? The doctor gave me the diagnosis and at the same time told me that during bronchoscopy, the samples which were taken from the lymph nodes and the right lung had been sent for genetic screening because that determines the treatment regimen and the genetic screening results will not be available for ten to fourteen days. So during that waiting period, I had a complete PET scan done, still waiting for the results which took about two weeks.

TEXT ON SCREEN:

Shobha’s complete diagnosis is metastatic non-small cell lung cancer with the epidermal growth factor receptor (EGFR) exon 19 deletion mutation.

SHOBHA

My physician called me actually and told me they found that it is EGFR mutation…

TEXT ON SCREEN:

A “mutation” is any change in the DNA sequence of a cell. In metastatic non-small cell lung cancer, biomarker testing can help doctors find out detailed information about a tumor, including mutations that may be present, which can help determine treatment options for your type of lung cancer.

TAGRISSO® (osimertinib) is a once-daily pill for metastatic non-small cell lung cancer that has certain abnormal EGFR genes. TAGRISSO is available, by prescription only, as an 80-mg tablet.

SHOBHA

While waiting to get final confirmation on the genetic testing, my husband and I had looked up what the different treatment options were available and also looked up that if it is EGFR positive, what are the choices? And TAGRISSO was described in the literature.

TEXT ON SCREEN:

TAGRISSO is a prescription medication for non-small cell lung cancer that has spread to other parts of the body.

VOICE OVER AND TEXT ON SCREEN:

TAGRISSO is used as a first treatment if tumors have certain abnormal epidermal growth factor receptor genes. TAGRISSO is available, by prescription only, as an 80-mg tablet.

TEXT ON SCREEN:

TAGRISSO can cause serious side effects. These can lead to death.

SHOBHA:

This medication is a pill that you take it once a day. I did have a little issue of diarrhea. Maybe a little dry skin. In my spare time, I really like to do things more with my hands. Cooking is one of my passions. Outdoor walking, especially gardening and I like to grow my own vegetables. When I was young, my mother who was also a very involved artist and taught us a lot of stuff. So she taught me how to make flowers out of crepe paper. I like to do a lot of craft. I don't have any formal training with it. I just find ways of doing or achieving the final thing in my own way.

SID:

She has always been the person who motivates everybody. Me, my children, our children. I mean we are always motivated by her. But that is the time when I first time I saw that she's ready to take a nap. She's tired. Her mind was going but her body was not. It was giving up and she was coughing. That made her more weak and tired which is not like her.

SHOBHA:

The moment he saw that I'm unable to handle everything physically, he was there. And the rest of the chores, rest of the responsibilities, he just took it over so that I could sleep. I mean, there were times I was going to bed at 8:30 and I couldn't keep up beyond that. I would say that I'm probably utilizing my time much more effectively now that, okay, I can squeeze in more to achieve more and a little more extra drive for that matter now. And just being grateful that we have…it's a chance I've gotten again to be able to complete pretty much what I wanted from this life.

TEXT ON SCREEN:

For patients with metastatic non-small cell lung cancer, the time from biomarker testing to receiving results varies. Talk to your doctor about your treatment plan.

SHOBHA:

Once a person has a diagnosis of lung cancer and having gone through what I have gone through, my advice to any person with fresh diagnosis would be get a biopsy done as quickly as possible, send the samples for genetic testing. You don't want to start on a therapy which is not what is going to benefit you. You want to right up-front start, no trial and error, you want to do it correct right from the beginning. And that's only achievable if you have genetic testing done.

VOICE OVER AND TEXT ON SCREEN:

TAGRISSO is an FDA-approved oral targeted therapy for metastatic non-small cell lung cancer with certain abnormal EGFR gene(s). TAGRISSO may cause serious side effects. These could lead to death. Tell your doctor right away if you have lung problems, such as trouble breathing, shortness of breath, cough, or fever; heart problems, such as pounding or racing, swelling of your ankles and feet, feeling lightheaded; eye problems, such as watery, red, sensitive, or painful eyes; or skin problems, such as skin reactions that look like rings, or severe blistering or peeling of the skin. Tell your doctor about all your medical conditions and any medicines you take, and if you are pregnant or plan to become pregnant, or are breastfeeding. The most common side effects of TAGRISSO are diarrhea, rash, dry skin, changes in your nails, mouth sores, tiredness, and decreased appetite. These are not all the possible side effects.

TEXT ON SCREEN: Please see Important Safety Information and full Prescribing Information for TAGRISSO, including Patient Information, available at TAGRISSO.com. If you can’t afford your medication, AstraZeneca may be able to help.

TAGRISSO is a registered trademark of the AstraZeneca group of companies. ©2020 AstraZeneca. All rights reserved. US-34953 Last Updated 1/20

VOICE OVER:

Please see Important Safety Information and full Prescribing Information for TAGRISSO, including Patient Information, available at Tagrisso.com. If you can’t afford your medication, AstraZeneca may be able to help.

Is TAGRISSO® (osimertinib) right for you?

Dr Sarada Gurubhagavatula explains what people should know about TAGRISSO® (osimertinib). Watch as Dr G discusses TAGRISSO, specific questions to ask your doctor, and what she wants you to know after diagnosis.

Official video from TAGRISSO® (osimertinib) 80-mg tablet from AstraZeneca (intended for US residents only).

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TEXT ON SCREEN: YOUR TEAM, TESTING, AND TREATMENT

of metastatic non-small cell lung cancer

TEXT ON SCREEN: SARADA GURUBHAGAVATULA, MD “DR G.” Medical Oncologist

Summit Medical Group

DR GURUBHAGAVATULA:

Hi, my name is Dr Sarada Gurubhagavatula. My patients call me Dr G and I’m a medical oncologist in Morristown, New Jersey. My specialty is in taking care of patients with lung cancer.

If you were recently diagnosed with late-stage lung cancer…

TEXT ON SCREEN:

Metastatic means cancer has spread to other parts of your body.

DR GURUBHAGAVATULA:

…it’s important for you to see several different types of doctors throughout your diagnosis and treatment.

The doctors are called specialists and each is well trained to provide a specific role in your care.

TEXT ON SCREEN:

Diagnosis and treatment take a team.

DR GURUBHAGAVATULA:

The medical oncologist, like me, is the doctor who leads your lung cancer team. The medical oncologist will also develop a treatment plan with you for each step of your care.

Make sure you partner with a medical oncologist whom you trust and with whom you feel comfortable. That’s really important.

Other key members, like oncology nurses or nurse practitioners, may also help guide your treatment and answer your questions.

TEXT ON SCREEN:

Your health care team will focus on what’s best for you.

DR GURUBHAGAVATULA:

Know the members of your team and their roles, and lean on your support team.

TEXT ON SCREEN:

Your health care team will focus on what’s best for you.

DR GURUBHAGAVATULA:

Remember that your entire lung cancer team works together to provide the best care for you.

TEXT ON SCREEN:

WHY BIOMARKER TESTING IS IMPORTANT

DR GURUBHAGAVATULA:

There’s a lot of reason to have hope even in the face of a diagnosis of lung cancer.

TEXT ON SCREEN: Healthy Lung Cells

Does this cancer cell have any biomarkers?

DR GURUBHAGAVATULA:

Now with biomarker testing, patients may have other options than starting with chemotherapy.

TEXT ON SCREEN:

Healthy Lung Cells

Does this cancer cell have any biomarkers?

TEXT ON SCREEN:

Now with biomarker testing, patients may have other options than starting with chemotherapy.

TEXT ON SCREEN:

Healthy Lung Cells

Does this cancer cell have any biomarkers?

Biomarker testing can identify certain mutations, such as EGFR, which can be treated with targeted therapy.

DR GURUBHAGAVATULA:

Finding out which biomarkers you have, such as EGFR, can help determine treatment options for your type of lung cancer.

TEXT ON SCREEN: Targeted therapies help
  • Stop the growth and spread of specific types of lung cancer cells

Targeted therapies are NOT chemotherapy or immunotherapy.

DR GURUBHAGAVATULA:

If your cancer tests positive for a biomarker…

TEXT ON SCREEN: Targeted therapies help
  • Stop the growth and spread of specific types of lung cancer cells

Targeted therapies are NOT chemotherapy or immunotherapy.

DR GURUBHAGAVATULA:

…you may be treated with a targeted therapy.

TEXT ON SCREEN:

TAGRISSO IS A TARGETED TREATMENT

DR GURUBHAGAVATULA:

If you were newly diagnosed with metastatic non-small cell lung cancer with an EGFR gene mutation…

TEXT ON SCREEN: If you are diagnosed with metastatic non-small cell lung cancer with an EGFR gene mutation, make sure you understand:
  • Why biomarker testing is important
  • All available treatment options
  • Your doctor’s experience treating EGFR positive non-small cell lung cancer
DR GURUBHAGAVATULA: …make sure you understand
  • why biomarker testing is important
  • all available treatment options and
  • your doctor’s experience treating EGFR positive non-small cell lung cancer

You may be able to take TAGRISSO as a first treatment after an EGFR-positive diagnosis.

TEXT ON SCREEN:

TAGRISSO is a targeted therapy for metastatic non-small cell lung cancer that tests positive for certain abnormal EGFR gene mutations.

DR GURUBHAGAVATULA:

TAGRISSO is a treatment for metastatic non-small cell lung cancer that has tested positive for certain types of abnormal EGFR genes.

TEXT ON SCREEN: TAGRISSO 80 mg One pill, once a day

Can be taken with or without food

DR GURUBHAGAVATULA:

TAGRISSO is a targeted therapy. It is given as a once-daily pill. TAGRISSO is not chemotherapy.

Here are some key questions you should ask your doctor about TAGRISSO:

TEXT ON SCREEN: TAGRISSO 80 mg One pill, once a day Can be taken with or without food

Ask your doctor, “Is TAGRISSO right for me?”

DR GURUBHAGAVATULA:

First, is TAGRISSO right for me?

TEXT ON SCREEN: TAGRISSO 80 mg One pill, once a day Can be taken with or without food

Ask your doctor, “Why may TAGRISSO be my best option?”

DR GURUBHAGAVATULA:

Why may TAGRISSO be my best option?

TEXT ON SCREEN: TAGRISSO 80 mg One pill, once a day Can be taken with or without food

Ask your doctor, “How should I take TAGRISSO?”

DR GURUBHAGAVATULA:

How should I take TAGRISSO?

TEXT ON SCREEN: TAGRISSO 80 mg One pill, once a day Can be taken with or without food

Ask your doctor, “How does TAGRISSO work?”

DR GURUBHAGAVATULA:

How does TAGRISSO work?

TEXT ON SCREEN: TAGRISSO 80 mg One pill, once a day Can be taken with or without food

Ask your doctor, “What Important Safety Information do I need to know about TAGRISSO?”

DR GURUBHAGAVATULA:

What Important Safety Information do I need to know about TAGRISSO?

TEXT ON SCREEN AND VOICE OVER:

TAGRISSO is an FDA-approved oral targeted therapy for metastatic non-small cell lung cancer with certain abnormal EGFR gene(s).

TAGRISSO may cause serious side effects. These could lead to death. Tell your doctor right away if you have lung problems, such as trouble breathing, shortness of breath, cough, or fever; heart problems, such as pounding or racing, swelling of your ankles and feet, feeling lightheaded; eye problems, such as watery, red, sensitive, or painful eyes; or skin problems, such as skin reactions that look like rings, or severe blistering or peeling of the skin. Tell your doctor about all your medical conditions and any medicines you take, and if you are pregnant or plan to become pregnant, or are breastfeeding.

The most common side effects of TAGRISSO are diarrhea, rash, dry skin, changes in your nails, mouth sores, tiredness, and decreased appetite. These are not all the possible side effects.

Please see Important Safety Information and full Prescribing Information for TAGRISSO, including Patient Information, available at TAGRISSO.com

If you can’t afford your medication, AstraZeneca may be able to help.

TEXT ON SCREEN:

Please see Important Safety Information and full Prescribing Information for TAGRISSO, including Patient Information, available at TAGRISSO.com

If you can't afford your medication, AstraZeneca may be able to help.

TAGRISSO is a registered trademark of the AstraZeneca group of companies. ©2020 AstraZeneca. All rights reserved. US-36235 Last Updated 1/20

What to expect after diagnosis—TAGRISSO® (osimertinib)

Being diagnosed can come as a complete shock. We asked Dr Douglas Reznick to explain the testing that comes after your initial diagnosis and what that means when selecting a treatment option. Watch as Dr Reznick discusses how TAGRISSO® (osimertinib) may be a viable treatment option to discuss with your doctor.

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TEXT ON SCREEN: Metastatic non-small cell lung cancer:

WHAT TO EXPECT AFTER DIAGNOSIS

TEXT ON SCREEN: DR DOUGLAS REZNICK Medical Oncologist

Rocky Mountain Cancer Centers

DR REZNICK:

My name is Dr Douglas Reznick. I’m a medical oncologist in Denver, Colorado, with Rocky Mountain Cancer Centers.

Today, we’ll be talking about testing and treatment decisions for…

TEXT ON SCREEN:

Metastatic means cancer has spread to other parts of your body.

DR REZNICK:

…metastatic non-small cell lung cancer. Specifically, what you can expect after initial diagnosis of metastatic non-small cell lung cancer is made.

TEXT ON SCREEN:

WHAT ARE SOME IMPORTANT THINGS TO KNOW ABOUT LUNG CANCER?

TEXT ON SCREEN: There are 2 types of lung cancer:
  • Non-small cell lung cancer
  • Small cell lung cancer
DR REZNICK:

There are 2 types of lung cancer—non-small cell lung cancer and small cell lung cancer.

TEXT ON SCREEN:

80%–85% of lung cancer cases are non-small cell lung cancer

DR REZNICK:

Non-small cell lung cancer is the most common type of lung cancer, accounting for 80% to 85% of all lung cancers diagnosed.

If you have metastatic non-small cell lung cancer, it’s important that you know what to expect.

If it hasn’t been already, your cancer should be tested to determine the type and for biomarkers. Biomarkers are used to determine your best treatment options for your type of cancer.

TEXT ON SCREEN:

WHY IS TUMOR TESTING SO IMPORTANT?

DR REZNICK:

Testing is important…

TEXT ON SCREEN:

Biomarkers can help doctors find out detailed information about a tumor.

DR REZNICK:

…because it helps identify biomarkers that determine the best…

TEXT ON SCREEN:

Biomarkers can help doctors find out detailed information about a tumor.

DR REZNICK:

…treatment options for your type of cancer.

TEXT ON SCREEN: Healthy Lung Cells

Does this cancer cell have any biomarkers?

Biomarkers can be found:

  • On the surface of the cells
  • Within the genes that program cells

They can also be found in the blood.

DR REZNICK:

An important advance in managing lung cancer has been the discovery of certain molecules that give doctors a more detailed picture of the tumor.

These are called biomarkers, found on the surface of the cells or within the genes that program these cells.

TEXT ON SCREEN:

2 ways to test:

  • Biopsy = tissue is removed from a tumor
  • Liquid biopsy = a blood test
DR REZNICK:

Testing is done as either a biopsy, where tissue is removed from a tumor, or a blood test, also known as a liquid biopsy.

TEXT ON SCREEN: Common biomarkers for non-small cell lung cancer:
  • EGFR
  • ALK
  • PD-L1
  • BRAF
  • ROS1
DR REZNICK:

Your cancer may be tested for these common biomarkers: EGFR, ALK, PD-L1, BRAF, and ROS1.

Finding out which biomarker you have, such as an EGFR, can help determine treatment options for your type of lung cancer.

Biomarker testing is a key step in your complete diagnosis.

TEXT ON SCREEN: WHAT SHOULD YOU ASK YOUR DOCTOR?
DR REZNICK:

Be sure to ask your physician if you have been tested for the EGFR biomarker.

If you have been diagnosed with the EGFR-positive lung cancer, you should ask your doctor the following.

TEXT ON SCREEN: Ask your doctor, “What does testing positive for an EGFR biomarker mean for my treatment options?”
DR REZNICK:

What does this mean for my treatment and…

TEXT ON SCREEN: Ask your doctor, “Will I need chemotherapy?”
DR REZNICK:

…will I need chemotherapy?”

TEXT ON SCREEN: Targeted therapies help
  • Stop the growth and spread of specific types of lung cancer cells

Targeted therapies are NOT chemotherapy or immunotherapy.

DR REZNICK:

The recommended practice for treating EGFR-positive lung cancer is to initiate with a targeted therapy.

Targeted therapies are specifically designed to be effective against certain biomarkers…

TEXT ON SCREEN: Targeted therapies help
  • Stop the growth and spread of specific types of lung cancer cells

Targeted therapies are NOT chemotherapy or immunotherapy.

DR REZNICK:

…such as EGFR.

DR REZNICK:

TAGRISSO is a targeted therapy proven to work in people with EGFR-positive lung cancer. TAGRISSO is not a form of chemotherapy. TAGRISSO is a once-daily pill.

TEXT ON SCREEN:

TAGRISSO® (osimertinib) is proven to give people significantly more time without tumors growing or spreading

Based on results from a clinical study, the median time before tumors started growing or spreading was 18.9 months for people taking TAGRISSO and 10.2 months for those taking other targeted therapies, erlotinib or gefitinib.

Median is the middle number in a range of numbers.

DR REZNICK:

In a clinical study, TAGRISSO showed groundbreaking results for the treatment of metastatic non-small cell lung cancer with certain types of abnormal EGFR genes. This study…

TEXT ON SCREEN:

TAGRISSO® (osimertinib) is proven to give people significantly more time without tumors growing or spreading

Based on results from a clinical study, the median time before tumors started growing or spreading was 18.9 months for people taking TAGRISSO and 10.2 months for those taking other targeted therapies, erlotinib or gefitinib.

Median is the middle number in a range of numbers.

DR REZNICK:

…compared TAGRISSO with EGFR-targeted therapies.

TEXT ON SCREEN: TAGRISSO 80 mg One pill, once a day Can be taken with or without food

Ask your doctor, “Is TAGRISSO right for me?”

DR REZNICK:

If you’ve been diagnosed with the EGFR-positive lung cancer, you should ask your doctor, “Is TAGRISSO right for me?”

TEXT ON SCREEN AND VOICE OVER:

TAGRISSO is an FDA-approved oral targeted therapy for metastatic non-small cell lung cancer with certain abnormal EGFR gene(s).

TAGRISSO may cause serious side effects. These could lead to death. Tell your doctor right away if you have lung problems, such as trouble breathing, shortness of breath, cough, or fever; heart problems, such as pounding or racing, swelling of your ankles and feet, feeling lightheaded; eye problems, such as watery, red, sensitive, or painful eyes; or skin problems, such as skin reactions that look like rings, or severe blistering or peeling of the skin. Tell your doctor about all your medical conditions and any medicines you take, and if you are pregnant or plan to become pregnant, or are breastfeeding.

The most common side effects of TAGRISSO are diarrhea, rash, dry skin, changes in your nails, mouth sores, tiredness, and decreased appetite. These are not all the possible side effects.

Please see Important Safety Information and full Prescribing Information for TAGRISSO, including Patient Information, available at TAGRISSO.com

If you can’t afford your medication, AstraZeneca may be able to help.

TEXT ON SCREEN:

Please see Important Safety Information and full Prescribing Information for TAGRISSO, including Patient Information, available at TAGRISSO.com

If you can't afford your medication, AstraZeneca may be able to help.

TAGRISSO is a registered trademark of the AstraZeneca group of companies. ©2020 AstraZeneca. All rights reserved. US-36234 Last Updated 1/20

A diagnosis could change everything—TAGRISSO® (osimertinib)

Being diagnosed can come as a complete shock. It’s natural to feel overwhelmed and concerned about how your diagnosis may impact you and your family. You may worry that everything will change. Instead, rethink treatment. Picture what the right treatment for your lung cancer could mean for you. Ask your doctor to test for the EGFR biomarker to find out if TAGRISSO® (osimertinib) may be right for your type of metastatic lung cancer. Learn more at https://tagrisso.az/Safety.

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TEXT ON SCREEN:

Lung cancer changes everything…

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It’s time to change how you think about treatment.

TEXT ON SCREEN: TAGRISSO is for metastatic non-small cell lung cancer that has certain abnormal EGFR genes. 80 mg available by prescription only.

TAGRISSO® osimertinib

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TAGRISSO® osimertinib

Rethink lung cancer treatment. TEXT ON SCREEN: TAGRISSO® osimertinib Find out if TAGRISSO is right for your lung cancer.

Ask your doctor to test for the EGFR biomarker.

TEXT ON SCREEN: TAGRISSO is an FDA approved oral targeted therapy for metastatic non-small cell lung cancer with certain abnormal EGFR genes. TAGRISSO may cause serious side effects. These could lead to death. Tell your doctor right away if you have lung problems, such as trouble breathing, shortness of breath, cough, or fever; heart problems, such as pounding or racing, swelling of your ankles and feet, or feeling lightheaded; or eye problems. Tell your doctor about all of your medical conditions and any medicines you take, and if you are or plan to become pregnant or are breastfeeding. The most common side effects of TAGRISSO are diarrhea, rash, dry skin, changes in your nails, mouth sores, tiredness, and decreased appetite. TAGRISSO.com

TAGRISSO® osimertinib

TEXT ON SCREEN: TAGRISSO.com 1-800-236-9933 TAGRISSO® osimertinib

Please see Important Safety Information and full Prescribing Information, including Patient Information, located in the TAGRISSO waiting room brochure.

If you can’t afford your medication, AstraZeneca may be able to help.

TAGRISSO is a registered trademark of the AstraZeneca group of companies. ©2018 AstraZeneca. All rights reserved. US-24674 Last Updated 11/18

VOICE OVER:

If you can’t afford your medication, AstraZeneca may be able to help.

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Important Safety Information

TAGRISSO may cause serious side effects, including:

  • lung problems. TAGRISSO may cause lung problems that may lead to death. Symptoms may be similar to symptoms from lung cancer. Tell your doctor right away if you have any new or worsening lung symptoms, including trouble breathing, shortness of breath, cough, or fever
  • heart problems, including heart failure. TAGRISSO may cause heart problems that may lead to death. Your doctor should check your heart function before you start taking TAGRISSO and during treatment as needed. Tell your doctor right away if you have any of the following signs and symptoms of a heart problem: feeling like your heart is pounding or racing, shortness of breath, swelling of your ankles and feet, feeling lightheaded
  • eye problems. TAGRISSO may cause eye problems. Tell your doctor right away if you have symptoms of eye problems which may include watery eyes, sensitivity to light, eye pain, eye redness, or vision changes. Your doctor may send you to see an eye specialist (ophthalmologist) if you get eye problems with TAGRISSO
  • skin problems. TAGRISSO may cause skin problems. Tell your doctor right away if you develop target lesions (skin reactions that look like rings), severe blistering or peeling of the skin
Important Safety Information

TAGRISSO may cause serious side effects, including:

  • lung problems. TAGRISSO may cause lung problems that may lead to death. Symptoms may be similar to symptoms from lung cancer. Tell your doctor right away if you have any new or worsening lung symptoms, including trouble breathing, shortness of breath, cough, or fever
  • heart problems, including heart failure. TAGRISSO may cause heart problems that may lead to death. Your doctor should check your heart function before you start taking TAGRISSO and during treatment as needed. Tell your doctor right away if you have any of the following signs and symptoms of a heart problem: feeling like your heart is pounding or racing, shortness of breath, swelling of your ankles and feet, feeling lightheaded
  • eye problems. TAGRISSO may cause eye problems. Tell your doctor right away if you have symptoms of eye problems which may include watery eyes, sensitivity to light, eye pain, eye redness, or vision changes. Your doctor may send you to see an eye specialist (ophthalmologist) if you get eye problems with TAGRISSO
  • skin problems. TAGRISSO may cause skin problems. Tell your doctor right away if you develop target lesions (skin reactions that look like rings), severe blistering or peeling of the skin

Before taking TAGRISSO, tell your doctor about all of your medical conditions, including if you:

  • have lung or breathing problems
  • have heart problems, including a condition called long QTc syndrome
  • have problems with your electrolytes, such as sodium, potassium, calcium or magnesium
  • have a history of eye problems
  • are pregnant or plan to become pregnant. TAGRISSO can harm your unborn baby. Tell your doctor right away if you become pregnant during treatment with TAGRISSO or think you may be pregnant
    • Females who are able to become pregnant should use effective birth control during treatment with TAGRISSO and for 6 weeks after the final dose of TAGRISSO
    • Males who have female partners that are able to become pregnant should use effective birth control during treatment with TAGRISSO and for 4 months after the final dose of TAGRISSO
  • are breastfeeding or plan to breastfeed. It is not known if TAGRISSO passes into your breast milk. Do not breastfeed during treatment with TAGRISSO and for 2 weeks after your final dose of TAGRISSO. Talk to your doctor about the best way to feed your baby during this time

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements. Especially tell your doctor if you take a heart or blood pressure medicine

The most common side effects of TAGRISSO are:

  • diarrhea
  • rash
  • dry skin
  • changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from nailbed, and shedding of nails
  • mouth sores
  • tiredness
  • decreased appetite

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of TAGRISSO. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-fda-1088.

What is TAGRISSO?

TAGRISSO is a prescription medicine for non-small cell lung cancer (NSCLC) that has spread to other parts of the body (metastatic). TAGRISSO is used:

  • as a first treatment if tumors have a certain abnormal epidermal growth factor receptor (EGFR) gene(s)
  • or
  • if you have a certain type of EGFR gene and were previously treated with an EGFR tyrosine kinase inhibitor (TKI) medicine that did not work or is no longer working

Your doctor will perform a test to make sure that TAGRISSO is right for you.

It is not known if TAGRISSO is safe and effective in children.

Please see full Prescribing Information including Patient Information.

You may report side effects related to AstraZeneca products by clicking here.