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EGFR is a type of protein found on the surface of cells in the body. However, when this protein is mutated and becomes too active, it can lead to cancer growth. Approximately 15% of patients with advanced NSCLC have tumors that are EGFR mutation positive.

Most advanced lung cancer will eventually progress, meaning the cancer will worsen, despite previous treatments. This is because the tumors become resistant to TKI therapy. In people who have EGFR mutation-positive NSCLC and have progressed on certain EGFR TKI therapies, the T790M mutation is related to progression of the disease in almost 2 out of 3 cases. T790M is a mutation that develops in response to first-line treatment of the EGFR mutation. It must be detected by a new test after disease progression occurs.

TYROSINE KINASE INHIBITORS

If you (or your loved one) were diagnosed with EGFRm+ non-small cell lung cancer, you were likely treated with a tyrosine kinase inhibitor (TKI) that targeted the EGFR protein on your lung cancer cells. It was designed to attach to the EGFR proteins with the goal of slowing down the growth of the cancer cells or making the tumors smaller. This line of therapy may have helped your tumors to shrink, or stay the same size, for a period of time.

IF YOU WERE TREATED WITH CHEMOTHERAPY

Sometimes doctors will choose to use chemotherapy as part of your treatment regimen, either before or along with a TKI. Learn how TAGRISSO is different than chemotherapy

Testing for the T790M mutation can identify an oral targeted therapy that may help

If you have metastatic EGFRm+ NSCLC that has progressed on or after a previous TKI treatment, and you have been told your tumors have the T790M mutation, an oral targeted therapy may be right for you.

TAGRISSO may cause serious side effects, including:

  • lung problems. TAGRISSO may cause lung problems that may lead to death. Symptoms may be similar to those symptoms from lung cancer. Tell your doctor right away if you have any new or worsening lung symptoms, including trouble breathing, shortness of breath, cough, or fever

  • heart problems, including heart failure. TAGRISSO may cause heart problems that may lead to death. Your doctor should check your heart function before you start taking TAGRISSO and during treatment as needed. Tell your doctor right away if you have any of the following signs and symptoms of a heart problem: feeling like your heart is pounding or racing, shortness of breath, swelling of your ankles and feet, feeling lightheaded

  • eye problems. TAGRISSO may cause eye problems. Tell your doctor right away if you have symptoms of eye problems which may include watery eyes, sensitivity to light, eye pain, eye redness, or vision changes. Your doctor may send you to see an eye specialist (ophthalmologist) if you get eye problems with TAGRISSO

Before taking TAGRISSO, tell your doctor about all of your medical conditions, including if you:

  • have lung or breathing problems

  • have heart problems, including a condition called long QTc syndrome

  • have problems with your electrolytes, such as sodium, potassium, calcium or magnesium

  • have a history of eye problems

  • are pregnant or plan to become pregnant. TAGRISSO can harm your unborn baby. Tell your doctor right away if you become pregnant during treatment with TAGRISSO or think you may be pregnant.

    • Females who are able to become pregnant should use effective birth control during treatment with TAGRISSO and for 6 weeks after the final dose of TAGRISSO
    • Males who have female partners that are able to become pregnant should use effective birth control during treatment with TAGRISSO and for 4 months after the final dose of TAGRISSO
  • are breastfeeding or plan to breastfeed. It is not known if TAGRISSO passes into your breast milk. Do not breastfeed during treatment with TAGRISSO and for 2 weeks after your final dose of TAGRISSO. Talk to your doctor about the best way to feed your baby during this time

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements. Especially tell your doctor if you take a heart or blood pressure medicine.

The most common side effects of TAGRISSO are:

  • diarrhea

  • rash

  • dry skin

  • changes in your nails, including: redness, tenderness, pain, inflammation, brittleness, separation from nailbed, and shedding of nails

  • tiredness

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of TAGRISSO. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.1-800-FDA-1088.

What is TAGRISSO?

TAGRISSO is a prescription medicine used to treat non-small cell lung cancer... read more (NSCLC). TAGRISSO may be used when your non-small cell lung cancer has spread to other parts of the body and:

  • has a certain type of abnormal epidermal growth factor receptor (EGFR) gene, called T790M, and

  • you have had previous treatment with an EGFR tyrosine kinase inhibitor medicine and it has stopped working

Your doctor will perform a test to make sure that TAGRISSO is right for you.

It is not known if TAGRISSO is safe and effective in children.

Please see accompanying full Prescribing Information including Patient Information.